西湖凹陷西部斜坡带花港组、平湖组储层裂缝发育特征及有效裂缝测井识别

以西湖凹陷西斜坡花港组、平湖组致密砂岩储层为研究对象,通过录井资料分析及岩心和显微薄片观察,研究裂缝的宏观与微观发育特征及其影响因素.结果显示其主要发育层理缝和构造缝.层理缝主要为水平缝和低角度缝,且已被充填;构造缝主要为垂直缝和高角度缝,充填缝和未充填缝各占一半.裂缝的发育受岩性、单层厚度、断裂及地应力场的综合影响.在交会图法(定性)和概率判别法(半定量)研究的基础上,将岩心观察统计结果与常规测井曲线和成像测井成果相对比,综合预测与评价裂缝发育段,认为有利的裂缝发育层段为花港组下段和平湖组中下段.     

数字化转型背景下我国金融机构业务与技术融合发展的路径

近年来,我国金融行业数字化转型不断提速,金融机构数字化转型已迫在眉睫.金融机构面临的数字化转型环境包括3个方面:一是大数据走向跨界融合;二是人工智能加速发展;三是区块链等技术建立了新型连接关系.基于以上环境分析,文章认为金融机构数字化转型的核心在于业务与技术融合,需要在机制、组织、架构、人才和文化层面实行再造.     

科技创业孵化载体专业化发展问题与对策研究

进入新发展阶段后,科技创新创业活动对孵化服务提出了更高的要求,科技创业载体需要加快提升专业化、精准化服务能力.文章基于2016-2019年全国科技创业孵化载体发展数据,全面分析专业化科技创业孵化载体建设发展现状,剖析了科技创业孵化载体在专业化建设方面存在的方向不清、动力不足、能力不够、模式不明、机制不畅等问题,从建立评价指标体系、明确建设主体、提升服务能力、加强资源开放和政策供给等方面提出对策建议.     

Controllability of Quantum Systems with SU(1, 1) Dynamical Symmetry

This paper presents sufficient and necessary conditions for the propagator controllability of a class of infinite-dimensional quantum systems with SU(1, 1) dynamical symmetry through the isomorphic mapping to the non-unitary representation of SU(1, 1). The authors prove that the elliptic condition of the total Hamiltonian is both necessary and sufficient for the controllability and strong controllability. The obtained results can be also extended to control systems with SO(2, 1) dynamical symmetry.     

一类离散时间复杂网络系统的输出同步

利用线性稳定性理论和Lyapunov函数方法,研究了一类离散时间复杂网络系统的输出同步问题,得到了系统输出指数同步的充分性条件,数值算例表明了方法的有效性.     

Blockage of the NLRP3 inflammasome by MCC950 improves anti-tumor immune responses in head and neck squamous cell carcinoma

The NLRP3 inflammasome is a critical innate immune pathway responsible for producing active interleukin (IL)-1β, which is associated with tumor development and immunity. However, the mechanisms regulating the inflammatory microenvironment, tumorigenesis and tumor immunity are unclear. Herein, we show that the NLRP3 inflammasome was over-expressed in human HNSCC tissues and that the IL-1β concentration was increased in the peripheral blood of HNSCC patients. Additionally, elevated NLRP3 inflammasome levels were detected in tumor tissues of Tgfbr1/Pten 2cKO HNSCC mice, and elevated IL-1β levels were detected in the peripheral blood serum, spleen, draining lymph nodes and tumor tissues. Blocking NLRP3 inflammasome activation using MCC950 remarkably reduced IL-1β production in an HNSCC mouse model and reduced the numbers of myeloid-derived suppressor cells (MDSCs), regulatory T cells (Tregs) and tumor-associated macrophages (TAMs). Moreover, inhibiting NLRP3 inflammasome activation increased the numbers of CD4⁺ and CD8⁺ T cells in HNSCC mice. Notably, the numbers of exhausted PD-1⁺ and Tim3⁺ T cells were significantly reduced. A human HNSCC tissue microarray showed that NLRP3 inflammasome expression was correlated with the expression of CD8 and CD4, the Treg marker Foxp3, the MDSC markers CD11b and CD33, and the TAM markers CD68 and CD163, PD-1 and Tim3. Overall, our results demonstrate that the NLRP3 inflammasome/IL-1β pathway promotes tumorigenesis in HNSCC and inactivation of this pathway delays tumor growth, accompanied by decreased immunosuppressive cell accumulation and an increased number of effector T cells. Thus, inhibition of the tumor microenvironment through the NLRP3 inflammasome/IL-1β pathway may provide a novel approach for HNSCC therapy.     

关于检查井沉降与解决措施的研究

基于我国检查井施工中出现的不均匀沉降及相关施工问题的实际情况,针对导致上述问题出现的各方面原因进行分析,就优化设计、规范开挖及回填施工、强化检查井的砌筑等方面提出了相应解决措施.以期为我国市政管线建设中的检查井设计及施工提供借鉴.     

深水铺管船的动力定位能力评估系统

为解决评估铺管船作业能力的难题,提出一种适用于评估铺管船动力定位能力的方法,开发了动力定位能力评估程序系统,并针对高海况环境条件设计了优化的辅助作业方案.采用数值计算方法对铺管船作业期间的平均二阶力、风载荷以及流载荷进行仿真计算,建立了环境载荷与动力定位系统提供的推力之间的平衡关系,给出了用于评估铺管船动力定位能力的系统模块,采用动力定位能力包络线的方式表达动力评估结果.在高海况作业中给出安全建议,即采用辅助拖轮作用于船舶适当位置以增强动力定位能力,从而降低工程作业风险.     

财政性科技经费监管体系探析

我国初步建立了财政性科技经费监管体系,但是在监督主体、监督制度等方面还存在缺陷,科技经费监督出现诸多问题。建立要加强宏观层面的统筹规划,建立由政府、承担单位和外部主体上下联动、横向联合的立体监督体系。